Minor/Significance Unknown. Offidani E, Guidi J, Tomba E, et al. benzhydrocodone/acetaminophen, lorazepam. Please try after some time. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. lorazepam and perphenazine both increase sedation. lorazepam and amoxapine both increase sedation. Monitor Closely (1)stiripentol, lorazepam. Risk of resp. Profound sedation, respiratory depression, coma, and death may result if coadministered. Information last revised December 2022. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)clonidine, lorazepam. Enhanced metabolism incr levels of hepatotoxic metabolites. gemifloxacin increases levels of lorazepam by decreasing metabolism. lorazepam and ramelteon both increase sedation. Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Monitor Closely (1)lorazepam and cyclobenzaprine both increase sedation. lorazepam and prochlorperazine both increase sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.lorazepam, clozapine. lorazepam and tapentadol both increase sedation. sharing sensitive information, make sure youre on a federal Serious - Use Alternative (1)lorazepam, metoclopramide intranasal. Profound sedation, respiratory depression, coma, and death may result if coadministered. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity. Minor/Significance Unknown. Use Caution/Monitor. Elderly patients often require lower benzodiazepine doses due to slower metabolism of the drugs. Either increases toxicity of the other by pharmacodynamic synergism. loprazolam and lorazepam both increase sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Benzodiazepines are a new generation of drugs that almost totally replaced the older type of anti-anxiety drugs, barbiturates. . Use Caution/Monitor. Modify Therapy/Monitor Closely. Patient demographics, lorazepam, sodium oxybate. Monitor Closely (1)lorazepam and trimipramine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. 0000007240 00000 n Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor.lorazepam, loxapine. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: clozapine, kava, sodium oxybate (also known as gamma hydroxybutyrate or GHB).The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. 0000004769 00000 n lorazepam and zotepine both increase sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. lorazepam increases and albuterol decreases sedation. Either increases toxicity of the other by pharmacodynamic synergism. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Monitor Closely (1)lorazepam and nabilone both increase sedation. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. WebNSAID, and steroid drug conversion factors Opioid Drugs Equivalent Dose IV morphine 1 mg IV fentanyl 0.01 mg IV hydromorphone 0.15 mg Oral oxycodone 3 mg IV nalbuphine 1 mg Oral codeine 20 mg Benzodiazepines Equivalent Dose IV midazolam 1 mg IV lorazepam 0.5 mg Neuromuscular Blockers Equivalent Dose IV vecuronium 1 mg IV lorazepam increases and epinephrine decreases sedation. lorazepam and daridorexant both increase sedation. sufentanil SL, lorazepam. Monitor Closely (1)lorazepam and tramadol both increase sedation. lorazepam and lormetazepam both increase sedation. lorazepam and paliperidone both increase sedation. Use Caution/Monitor. lorazepam increases and epinephrine racemic decreases sedation. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Avoid or Use Alternate Drug. WebPharmacist initiated IV to PO conversion program of antimicrobials. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Either increases effects of the other by sedation. Conclusions: Patients treated with selinexor may experience neurological toxicities. Use Caution/Monitor. WebLorazepam (PO/IV): 0.025 - 0.1 mg/kg/dose (Max: 2 mg) Q4-6 Midazolam (PO) 0.25 - 0.5 mg/kg/dose (Max: 20 mg) PRN Voriconazole (IV/PO) 2 - 12 yo: 9 mg/kg/dose x 2 doses then 8 -9 mg/kg/dose Q12 12 yo: 6 mg/kg/dose x 2 doses then 3 - Minor/Significance Unknown. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Minor/Significance Unknown. desflurane and lorazepam both increase sedation. Severe adverse events associated with oversedation and/or withdrawal were minimal and confounded by underlying disease states. {+/7VPerb}6Wz+>8. Use Caution/Monitor. Minor/Significance Unknown. brimonidine increases effects of lorazepam by pharmacodynamic synergism. government site. Bethesda, MD 20894, Web Policies Then type a starting value in the top FROM input box. ofloxacin increases levels of lorazepam by decreasing metabolism. Either increases toxicity of the other by sedation. 0000006670 00000 n In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. Use Caution/Monitor. Symptoms of overdose may include confusion, slow reflexes, clumsiness, deep sleep, and loss of consciousness. lorazepam and dextromoramide both increase sedation. Either increases toxicity of the other by pharmacodynamic synergism. This conversion from intravenous (IV) to oral (PO) thera-py has been practiced in an uncon-trolled fashion since the earliest years of the anti-infective era. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. lorazepam and eucalyptus both increase sedation. Careers. Use Caution/Monitor. Always ask your health care professional for complete information about this product and your specific health needs. lorazepam increases and armodafinil decreases sedation. -yuRm]M In the case of converting morphine to methadone, methadone has a relative potency of 4:1 at lower morphine doses, but becomes much more potent (12:1) in patients converting from very high morphine doses. Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)cannabidiol will increase the level or effect of lorazepam by decreasing metabolism. lorazepam increases and diethylpropion decreases sedation. The authors have disclosed that they do not have any potential conflicts of interest. trailer Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Minor/Significance Unknown. use as abrupt D/C or rapid dose reduction may cause acute withdrawal reactions, potentially life-threatening. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Berlin A, Dahlstrm H. Pharmacokinetics of the anticonvulsant drug clonazepam evaluated from single oral and intravenous doses and by repeated oral administration. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Modify Therapy/Monitor Closely. Withdrawal Assessment ToolVersion 1 scores were compared pre and post benzodiazepine conversion. <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 792 612] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> WebLorazepam (Ativan ): Dosing (Adults): Anxiety/sedation: 1-10 mg orally in 2-3 divided doses. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. pregabalin, lorazepam. MISSED DOSE: If you miss a dose and are taking more than 1 dose daily, do not take it if it is almost time for the next dose. Retrospective cohort study evaluating the effectiveness and safety of benzodiazepine conversion calculations embedded within an institution-specific clinical pathway for sedation and weaning of mechanically ventilated pediatric patients. unspecified interaction mechanism. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. An IV Loading dose is 0.02 to 0.04 mg/kg (maximum single dose 2 mg); the Maintenance dose is 0.02 to 0.06 mg/kg every 2 to 6 hours as needed or 0.01 to 0.1 This work was performed at the Childrens Hospital of Philadelphia. Adv Emerg Nurs J. Applies only to oral form of both agents. Monitor Closely (1)lorazepam and mirtazapine both increase sedation. Use Caution/Monitor. 2021 Top Cited Articles in Pediatric Critical Care Medicine, 2020 Top Cited Articles in Pediatric Critical Care Medicine, 2019 Top Cited Articles in Pediatric Critical Care Medicine. lorazepam decreases effects of cisatracurium by pharmacodynamic antagonism. To convert the value, Modify Therapy/Monitor Closely. STOP-BANG calculator screens for the risk factors & symptoms of obstructive sleep apnea (OSA). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). and formulary information changes. lorazepam and levorphanol both increase sedation. Initial dose should not exceed 2 mg in Use lowest dose possible and monitor for respiratory depression and sedation. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Possible risk of cardiorespiratory collapse. Use Caution/Monitor. primidone and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Minor (1)lorazepam increases effects of vinpocetine by unspecified interaction mechanism. Use Caution/Monitor. Consult your pharmacist or local waste disposal company. Well, the benzodiazepine conversion calculator has got your back! WebATIVAN (lorazepam) Injection Rx only DESCRIPTION Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or Post conversion, one patient (1.4%) had increased seizure activity, and four patients (5.6%) required fluid boluses secondary to tachycardia or dehydration, but not hypotension. Use Caution/Monitor. Limit dosages and durations to the minimum required. In many, but not all of these cases, buprenorphine was misused by self-injection. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. brexanolone, lorazepam. Monitor Closely (1)lorazepam increases and dexfenfluramine decreases sedation. Initial: 2-3 mg PO q8-12hr PRN; not to exceed 10 mg/day, Maintenance: 2-6 mg/day PO divided q8-12hr, Indicated for anxiety disorders in adults who are receiving stable, evenly divided, TID dosing with lorazepam tablets, Recommended dose: Administer capsule PO qAM; dose equals the total daily dose of previously administered lorazepam tablets, Dosage adjustment: Discontinue Loreev XR and switch to lorazepam tablets to adjust dosage, 0.02-0.06 mg/kg intermittent IV q2-6hr PRN, OR, 0.01-0.1 mg/kg/hr continuous IV; not to exceed 10 mg/hr, IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment or renal failure, IV/IM (prolonged periods or high doses): Monitor; risk of propylene glycol toxicity, PO: No dose adjustment recommended in mild-to-moderate impairment; use with caution (may require lower dose) in severe impairment, IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment of hepatic failure, calcium/magnesium/potassium/sodium oxybates, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death, Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate, Limit dosages and durations to the minimum required, Follow patients for signs and symptoms of respiratory depression and sedation, On September 2020, FDA addressed serious risks of benzodiazepine addiction, abuse, and misuse, which can lead to overdose and death, Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes; before prescribing and throughout treatment, assess each patients risk for abuse, misuse, and addiction, Physical dependence can occur when taken steadily for several days to weeks, even as prescribed, Risks of dependence and withdrawal increase with longer treatment duration and higher daily dose; although injection is indicated only for intermittent use, if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction may precipitate acute withdrawal reactions, including seizures, which can be life-threatening; use gradual taper when discontinuing therapy to reduce withdrawal reactions risk, Assess each patients risk prior to prescribing and monitor regularly for the development of these conditions, Published animal studies demonstrate that administration of anesthetic and sedation drugs that block NMDA receptors and/or potentiate GABA activity increase neuronal apoptosis in developing brain and result in long-term cognitive deficits when used for longer than 3 hours; repeated exposure may also result in negative effects on fetal or young childrens brain development, Caution with use during surgeries or procedures in children younger than 3 yr or in pregnant women during their third trimester, Assess the risk:benefit ratio in these populations, especially for prolonged procedures (ie, >3 hr) or multiple procedures, Prior to use, dilute injection solution with an equal amount of compatible diluent (D5W, NS, SWFI), Administer IV injection slowly, directly into a vein or into tubing of a free-flowing, compatible IV infusion (eg, NS, D5W), at no more than 2 mg/min, Validate patent venous catheter with repeated aspiration during infusion to visualize venous blood return, Inadvertent intra-arterial injection may produce arteriospasm resulting in gangrene, potentially requiring amputation, Rapid IV infusion may result in apnea, bradycardia, hypotension, cardiac arrest, Continuous infusion solutions should have an in-line filter and should be checked frequently for possible precipitation, Emergency resuscitative equipment should be available when administering IV, Capsule may be opened and entire contents sprinkled onto a tablespoon of applesauce, Swallow within 2 hours of mixing; do not store mixture for future use, Drink a glass of water after swallowing mixture, Gradually taper dose to reduce risk of withdrawal reactions, If withdrawal reactions occur, consider pausing the taper or increasing the dosage to the previous tapered dosage level; subsequently decrease dosage more slowly. 0000010283 00000 n MEDICAL ALERT: Your condition can cause complications in a medical emergency. You should not become pregnant while using lorazepam. Effect of interaction is not clear, use caution. brompheniramine and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. vhaw%"(JDY]&3JlHlHl) V" 3Jl%6l)FDf 3Jl%Zm%6l$6l$6gISH`F 0$`:Y0[4(f =K&/hDX, UVW;ww$ZHTZHZ_IIb j o4+n%sRH5H5jKIWR5:R'R^IO^G_GUcy;tr.Rx`]5,u8VR@#fD'l Either increases effects of the other by sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and salmeterol decreases sedation. Monitor Closely (1)cinnarizine and lorazepam both increase sedation. teduglutide increases levels of lorazepam by Other (see comment). Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam and trifluoperazine both increase sedation. lorazepam increases and ephedrine decreases sedation. 0000005197 00000 n Data is temporarily unavailable. Use Caution/Monitor. Use Caution/Monitor. Oxazepam (Serax): the initial dose is 10-15 mg daily; the dose can be increased by 10 mg daily in divided doses (three times a day); the usual therapeutic dose is 90 mg total/day, with three times a day dosing. Monitor Closely (1)lorazepam and motherwort both increase sedation. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). If that's the drug you're taking, simply multiple your dose by the number that's present beside the name of the drug you want to switch to. Monitor Closely (1)lorazepam and flibanserin both increase sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. Severe adverse events associated with oversedation and/or withdrawal were minimal and confounded by underlying disease states. Effect of interaction is not clear, use caution. Either increases toxicity of the other by pharmacodynamic synergism. WebConverting from: ALPRAZolam (Xanax) ChlordiazePOXIDE (Librium) DiazePAM (Valium) ClonazePAM (KlonoPIN) LORazepam (Ativan) Oxazepam (Serax) Temazepam (Restoril) Triazolam (Halcion) Total daily drug dosage (mg) mg Converting to: ALPRAZolam Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. lorazepam increases and terbutaline decreases sedation. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use Caution/Monitor. Tell your doctor right away if you notice any of these effects.A very serious allergic reaction to this drug is rare. Use Caution/Monitor. Benzodiazepine conversion calculations were applied according to institutional clinical pathway guidance. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Cannabidiol may potentially inhibit UGT2B7 activity. Monitor Closely (1)lorazepam and maprotiline both increase sedation. Davidson JR. Use of benzodiazepines in social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. Minor/Significance Unknown. Monitor Closely (1)lorazepam and moxonidine both increase sedation. Unauthorized use of these marks is strictly prohibited. Monitor Closely (1)lorazepam and ziprasidone both increase sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. official website and that any information you provide is encrypted Use Caution/Monitor. lorazepam and metaxalone both increase sedation. Monitor Closely (1)lorazepam increases and diethylpropion decreases sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. lorazepam and pimozide both increase sedation. Monitor Closely (1)lorazepam and orphenadrine both increase sedation. Monitor Closely (1)pregabalin, lorazepam. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787140/all/Benzodiazepines Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Use Caution/Monitor. Minor (1)moxifloxacin increases levels of lorazepam by decreasing metabolism. Use Caution/Monitor. You may search for similar articles that contain these same keywords or you may Cannabidiol may potentially inhibit UGT2B7 activity. . Alprazolam: Safety has not been established in children, Chlordiazepoxide: Not recommended for children younger than 6 years of age. H\TKoAqs;O Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use Caution/Monitor. Clinical assessment is required prior to any changes in WebBenzodiazepine Dose and Route Equivalence Diazepam 10mg PO/PR 2.5mg subcut midazolam Clonazepam 1mg PO/SC Lorazepam 1mg PO/IV Oxazepam 15 to 30mg PO Temazepam 10mg PO Midazolam Nasal Spray 5 sprays (=2.5mg) Example: A patient has been taking 1 mg lorazepam PO (equivalent to 2.5 mg subcut midazolam) + used Select Try/Buy and follow instructions to begin your free 30-day trial. Benzodiazepine conversion calculations were applied according to institutional clinical pathway guidance. Effect of interaction is not clear, use caution. The list of benzodiazepines can be divided into 3 groups based on the duration of their action and the speed of the onset of action. Monitor Closely (1)difelikefalin and lorazepam both increase sedation. Talk with your doctor if this medication stops working well.Though it helps many people, this medication may sometimes cause addiction.
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