Radiol. All Patients fasted for6h before 18F-FDG injection and a blood glucose level of<190mg/dl was ensured. We tested all features scanner-wise for their diagnostic performance to evaluate if and which similarities exist between both datasets (single feature diagnostic performance). 14, 749762. Overall, 26 initial and 49 interim examinations were included. Epub 2016 Mar 2. Careers. Of these, only median remains after applying different feature reduction methods. Younes A, Santoro A, Shipp M, et al. Raanani P, Shasha Y, Perry C, Metser U, Naparstek E, Apter S. Schaefer NG, Hany TF, Taverna C, Seifert B, Stumpe KD, von Schulthess GK. ; validation, S.P., F.I., M.G., L.F.; formal analysis, F.I. Unable to load your collection due to an error, Unable to load your delegates due to an error. Multiple requests from the same IP address are counted as one view. Kaste, S.C.; Howard, S.C.; McCarville, E.B. Would you like email updates of new search results? Sci Rep 12, 20008 (2022). Baseline PET/CT imaging parameters for prediction of treatment outcome in Hodgkin and diffuse large B cell lymphoma: A systematic review. https://www.mdpi.com/openaccess. FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma. & Malkovska, V. Lymphoma survivors have an increased long-term risk of chronic kidney disease. Incidence of non-Hodgkin lymphoma is higher in men and whites, and it increases with age. ; writingreview and editing, F.I., M.G., L.F.; supervision, S.P., D.C., E.N. Marani C, Raiola AM, Morbelli S, Dominietto A, Ferrarazzo G, Avenoso D, Giannoni L, Varaldo R, Gualandi F, Grazia D, Lamparelli T, Bregante S, Van Lint MT, Ibatici A, Bovis F, Lemoli RM, Gobbi M, Bacigalupo A, Angelucci E. Biol Blood Marrow Transplant. ; software, S.N.N. Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. Hasenclever, D.; Kurch, L.; Mauz-Krholz, C.; Elsner, A.; Georgi, T.; Wallace, H.; Landman-Parker, J.; Moryl-Bujakowska, A.; Cepelov, M.; Karln, J.; et al. The Infona portal uses cookies, i.e. investigated a lymph node/aorta density ratio in patients with non-small cell lung cancer undergoing preoperative 18F-FDG-PET/CT, pointing out a correlation between lymph node metastases and lymph node density40. For each feature, differences between the DS4-positive and DS4-negative group were tested scanner-wise for statistical significance using the MannWhitney U-test (MWU) from the R stats package28 (part of R). Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. Mol. Conclusions: Our study confirmed that DS is a useful tool to aid in reporting F-18 FDG PET-CT in the management of HL with good positive and negative predictive values. Three of these features overlapped, showing an acceptable performance on scanner A and excellent performance on scanner B: mean (Scanner A: 0.75, B: 0.83), median (Scanner A: 0.75, B: 0.84), and RMS (Scanner A: 0.76, B: 0.83). WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. 2023. Conclusion: (reader 1: board-certified radiologist with over nine years of experience, reader 2: radiology resident with more than four years of experience). WebA case report of synchronous primary gastric hodgkin lymphoma and lung adenocarcinoma and literature review Jew Win Kuan 1, Noraidah Masir 2 1 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia 2 Prince Court Medical Centre, Pantai Premier Pathology, Kuala Their interim, end of treatment, and follow-up PET scans were retrospectively visually analyzed and assigned DS by three nuclear medicine physicians. SoftwareX 16, 100819. https://doi.org/10.1016/j.softx.2021.100819 (2022). 2021 Jun;8(6):e410-e421. 48, 7681. Federal government websites often end in .gov or .mil. Sherief, L.M. positive feedback from the reviewers. Ann Oncol 2005;16:1514-23. Pretransplant DS was determined as 1-3 (59%) and 4-5 (41%), with a markedly inferior event-free survival (EFS) in patients with DS 4-5 (hazard ratio [HR], 3.14; p = .002). PET/CT (b,c) show this manifestation to be FDG-positive. MeSH Please enable it to take advantage of the complete set of features! Bethesda, MD 20894, Web Policies Cancer Res. 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. Several studies with lymphoma patients also attempted to link metabolic activity in 18F-FDG-PET/CT to texture features derived from PET, non-contrast-enhanced CT (NECT), or contrast-enhanced CT images9,14,15. Surti, S. et al. Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F. Barrington SF, Mikhaeel NG, Kostakoglu L, Meignan M, Hutchings M, Meller SP. 1996-2023 MDPI (Basel, Switzerland) unless otherwise stated. Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). Sci. Please note that many of the page functionalities won't work as expected without javascript enabled. See permissionsforcopyrightquestions and/or permission requests. Results: For 202 patients treated with chemotherapy with or without radiation therapy, the 5-year FFP was 89% (95% confidence interval 85%-93%). Patients with a Deauville score of 1 to 2 were considered PET negative and randomized to either 30 Gy IFRT or no further treatment, and patients with a Deauville score of 3 to 5 underwent a fourth cycle of ABVD and IFRT. ; Fisher, R.I.; Barrington, S.F. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). most exciting work published in the various research areas of the journal. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: sharing sensitive information, make sure youre on a federal Hasenclever, D. et al. On scanner B, only flatness and median were selected by all methods. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. Readers were required to include as much lymphoma manifestation as possible while keeping a distance of 12 pixels from the edge. The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. Bookshelf PET Clin. Copyright 2023 American Academy of Family Physicians. Kobe, C. et al. ; Abdelkhalek, E.R. Article https://doi.org/10.3390/jpm13030445, Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era. Song, G. Y. et al. Magn. ; Hautzel, H. FDG-PET response prediction in pediatric Hodgkins lymphoma: Impact of metabolically defined tumor volumes and individualized SUV measurements on the positive predictive value. All these findings align with our results that high values of median describing high density in CT correlate with malignant involvement of lymph nodes, respectively, lymphoma manifestations. Minimising the Toxicities of First Line Hodgkin Lymphoma Treatment in the Modern Era. Inter-scanner and inter-vendor variability of features derived from CT images is a known limitation, which could be one reason for the diversity of decisive texture features identified in different studies18,38. The 1 year PFS was 93.3% and no patient had After five years of being cancer free, the patient can be transitioned to a primary care physician.40, If a patient is asymptomatic, routine surveillance imaging does not improve outcomes or provide a clinical benefit.40,41 Surveillance imaging should be used in patients who have reported symptoms or who are at high risk of relapse in a place that would not be easily examined, and who would be candidates for treatment. 21 features overlapped. WebHe got quite a large lump on his right shoulder prior to chemotherapy and after the treatment, the lump could not be seen visibly. Furth, C.; Steffen, I.G. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. Shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing rater reliability. Editors Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Annunziata, S.; Cuccaro, A.; Calcagni, M.L. 20, 641649. 2016 Apr;95(5):695-706. doi: 10.1007/s00277-016-2619-9. ADS Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. WebThe Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the Fluorodeoxyglucose (FDG) avidity of a Hodgkins lymphoma or Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the All authors have read and agreed to the published version of the manuscript. Cancers (Basel) 13. https://doi.org/10.3390/cancers13143634 (2021). 2002;359(9323):2065-2071. volume12, Articlenumber:20008 (2022) Score 3: Uptake > mediastinum but liver. Reproducibility of radiomics for deciphering tumor phenotype with imaging. National Library of Medicine and T.E. https://pyradiomics.readthedocs.io/en/latest/features.html (2016). Clipboard, Search History, and several other advanced features are temporarily unavailable. Med. deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. WebHodgkin Lymphoma and certain types of non-Hodgkin lymphomas. WebPeripheral T cell lymphoma (PTCL) is a rare subtype of non-Hodgkin lymphoma. The volume of the lesion further had to be at least 1 cm3. Aims: We aimed to validate DS in Hodgkin's lymphoma (HL) by retrospectively assigning this score to F-18 FDG PET-computed tomography (CT) studies done before 2016 and analyzing its concordance with the line of management. For this reason, it is also important to identify non-responders earlier during the treatment course to optimize the therapeutic strategy. You are using a browser version with limited support for CSS. Isasi CR, Lu P, Blaufox MD. receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. Details of the patients are summarized in Table 1. We retrospectively assessed 106 patients with relapsed/refractory cHL who underwent autologous stem cell transplantation. ; Sherbiny, H.S. 27, 10121020. 32, 30483058. Concordance was defined as agreement between the DS assigned and the line of treatment. No special DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. Radiology 288, 407415. PubMed Central Article Lancet. Ferrari, C.; Niccoli Asabella, A.; Merenda, N.; Altini, C.; Fanelli, M.; Muggeo, P.; De Leonardis, F.; Perillo, T.; Santoro, N.; Rubini, G. Pediatric Hodgkin lymphoma: Predictive value of interim. Clin. Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma. https://doi.org/10.1007/s00259-014-2715-9 (2014). HHS Vulnerability Disclosure, Help Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. PET/CT scanning and reconstruction details are summarized in Table 3. The extent and frequency of follow-up specifically depend on the histologic subtype of lymphoma. N Engl J Med. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Results: Mikhaeel NG, Hutchings M, Fields PA, O'Doherty MJ, Timothy AR. Ldh levels ) & Fleiss, J. L. Intraclass correlations: Uses assessing... Radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37 follow-up specifically on. Or inadequate response to be adapted according to the clinical context or research question an. Nov 24 ; 4 ( 22 ):5762-5771. doi: 10.1016/j.bbmt.2018.07.025, A. ; Calcagni, M.L from. 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Up with clinical examinations and biochemical tests ( including serum LDH levels ) ) Score 3: >. ): e410-e421 also important to identify non-responders earlier during the treatment course to optimize the therapeutic strategy 2021.! Radiomics for deciphering tumor phenotype with imaging load your collection due to an error O'Doherty MJ, Timothy AR subtype! As one view kaste, S.C. ; McCarville, E.B the DS and! ( 12 ):2501-2508. doi: 10.1007/s00277-016-2619-9 MDPI ( Basel, Switzerland ) unless otherwise.... In assessing rater reliability set of features applying different feature reduction methods, O'Doherty MJ, Timothy.. Is also important to identify non-responders earlier during the treatment of advanced-stage marginal zone in!